General

Scientific Names: Drynaria fortunei (Kunze) J. Sm.

Common Names: Gu Sui Bu, Hou Jiang, Shi Mao Jian, Guo Shan Long, Sui Bu.

BOTANICAL:

来 源： 为水龙骨科植物槲蕨Drynaria fortunei（Kunze）J.SM. 的干燥根茎。

植物特征： 槲蕨为附生植物；根状茎肥厚多肉，横走，密覆鳞片，鳞片线状凿形，边缘流苏状。叶二型，营养叶鳞片状斜贴于根茎上，可聚集腐殖质和水分，无柄，红棕色，常干膜质，阔卵形，长5～7厘米，宽3～6厘米，顶端短尖，上部羽状浅裂，裂片三角形，长1～l.5厘米，叶脉明显；孢子叶革质．轮廓为长圆形，连柄长25～40厘米，叶柄具狭翅，与根状茎有关节相连；叶片羽状深裂，裂片7～13对，互生，披针形，长7～9厘米，宽2～3厘米，顶端短尖或钝，基部裂片明显缩短呈耳状，叶脉明显，小脉连成长方形网眼；孢子囊群大，圆形．沿裂片中脉两旁排成2～4行，无囊群盖，环带有13个细胞，孢子两面型。

生药材鉴定： 根状茎长条状．明显平扁，中部常稍膨大，有分枝，常弯曲，长4～15厘米，宽1～2厘米，厚O.2～O.5厘米。表面棕色或棕褐色，密被深棕色、柔软如毛的小鳞片。两侧及上面均具边缘突起的圆形叶痕，间有叶柄残基和残存须根。体轻质脆，易折断，断面红棕色，微呈颗粒状，纤维束呈黄色小点状．排列成环。气微，味微涩。以粗大肥壮、无或少毛茸、质坚实者为佳。

Pharmacology

化学成分: 含橙皮甙(hesperidin)、柑橘素(naringenin)等。

Efficacy

The proliferative effects of thirty Oriental medicinal herbs on MCF-7 (estrogen-sensitive breast cancer cell line) and ROS 17/2.8 osteoblast-like cells were determined using the MTT assay. Methanol extracts from several herbs was found to show proliferative activity on the above two cell lines in the range of 5 to 100 microg/mL. Among these active herbs, the methanol extract from the rhizomes of Drynaria fortunei showed the most potent proliferative activity, and the cell proliferations were significantly increase by 136 and 158% in the MCF-7 and ROS 17/2.8 cells, respectively, when treated with 100 microg/mL. Through a bioassay-guided separation, eight flavonoids, including four new flavan-3-ols and two propelargonidins, together with the known (-)-epiafzelechin and naringin, were isolated. Their chemical structures were characterized as (-)-epiafzelechin (1), (-)-epiafzelechin-3-O-beta-D-allopyranoside (2), (-)-epiafzelechin-3-O-(6"-O-acetyl)-beta-D-allopyranoside (3), 4beta-carboxymethyl-(-)-epiafzelechin methyl ester (4), 4beta-carboxymethyl-(-)-epiafzelechin sodium salt (5), naringin (6), (-)-epiafzelechin-(4beta-->8)-4beta-carboxymethylepiafzelechin methyl ester (7) and (-)epiafzelechin-(4beta-->8, 2beta-->O-->7)-epiafzelechin-(4beta-->8)-epiafzelechin (8) by extensive 1D and 2D NMR spectroscopy. Most of these flavonoids, in the range of 10(-15) to approximately 10(-6) M, accelerated the proliferation of MCF-7 cell, with compounds 7 and 8, in the range of 10(-15) to approximately 10(-12) M, showing especially potent proliferation effects. Meanwhile, seven flavonoids, with the exception of compound 4, stimulated the proliferation of ROS 17/2.8 cells in the range of 10(-15) to approximately 10(-6) M, with compounds 5-8 especially accelerating the proliferation, in dose-dependent manners (10(-15) to approximately 10(-9) M), and their proliferative effect was much stronger than that of E2 and genistein. These results suggest that propelargonidin dimers and trimers isolated from the rhizomes of Drynaria fortunei may be useful as potential phytoestrogens, which play important physiological roles in the prevention of postmenopausal osteoporosis. (source)

IN VITRO:

1. Chang EJ, et al., Proliferative effects of flavan-3-ols and propelargonidins from rhizomes of Drynaria fortunei on MCF-7 and osteoblastic cells. Arch Pharm Res. 2003 Aug; 26(8):620-30.
   
   
   
   
   

Safety

宜忌: 阴虚及无瘀血者慎服。《本草经疏》："不宜与风燥药同用。" 《本草汇言》："如血虚风燥，血虚有火，血虚挛痹者，俱禁用之。" 《得配本草》： "忌羊肉、羊血、芸薹菜。"