General

Scientific Names: Glehnia littoralis Fr. Schmidt ex Miq.

Common Names: Shan Hu Cai, Lai Yang Shen, Sha Shen, Hai Sha Shen.

BOTANICAL:

来 源： 为伞形科(Umbelliferae)植物珊瑚菜( Glehnia littoralis Fr. Schmidt ex Miq. ) 的根。

植物特征: 多年生草本，高7～35cm。全体有灰褐色绒毛。主根圆柱形，长可达30cm。茎大部分埋在砂中，直立，不分枝。叶互生，质厚。长6～10cm，宽2.5～4cm，三出分裂至二回羽状全裂，边缘具粗齿牙；叶柄长约10cm。复伞形花序顶生；无总苞；总梗长4～10cm；小总苞片8～12。条状披针形；花草5齿裂；花瓣5，白色，卵形；雄蕊5；子房下位，花柱2。双悬果圆球形或椭圆形。花期5～6月，果期6～7月。

生药材鉴定： 去皮沙参细长，圆柱形，顶端略细，中部稍粗，下端渐细。表面谈黄白色，粗糙，有细纵皱纹或沟纹及细小裂隙，全体糊化，角质样。质硬而脆，易折断，断面不整齐，有射线状花纹，中部有白色或淡黄色木质心，形成层环状，棕黄色，韧皮部淡黄白色。以根条细长、均匀、质坚脆者为佳。

资源分布: 生于海边沙滩，或栽培于肥沃疏松的沙质土壤。分布于辽宁、河北、山东、江苏、浙江、福建、广东、海南、台湾。

Pharmacology

化学成分: 根含珊瑚菜素(phellopterin)，佛手柑内酯(bergapten)，补骨脂素(psoralen)，花椒毒素(xanthot—oxin)，花椒毒酚，8—牻牛儿补骨脂素，马米辛、印度榅桲素(marmesin)，佛手柑亭(bergaptin)，欧前胡素 (imperatorin)等。

Efficacy

Using flow cytometry the authors analysed the effect of 24 Chinese medicinal herbs (CMH) in compound recipe on proliferation index (PI), DNA index, protein index and ratio of various phases in cell cycle of human lung adenocarcinoma cell (SPC-A-1), The PI were more than 20%, in 4 CMH, while 3 CMH such as Gynostemma pentaphyllum, Glehnia littoralis, Panax Ginseng, could strengthen the body resistance. That suggested using CMH of strengthening body resistance not only served as conventional tonice but also as tumor cell inhibitor. Meanwhile the action point of 24 CMH on cell cycle were different. Therefore according to these results a new recombined Chinese recipe would be more effectively used for clinical practice. (source)

北沙参能提高 T 细胞比值，提高淋巴细胞转化率，升高白细胞，增强巨噬细胞功能。延长抗体存在时间，提高 B 细胞，促进免疫功能。 (source)

IN VITRO:

1. Han MQ, et al., [Effects of 24 Chinese medicinal herbs on nucleic acid, protein and cell cycle of human lung adenocarcinoma cell]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Mar; 15(3):147-9. Chinese.
   

Safety